Drug information
| Name | |
| ChEMBL ID | |
| SMILES | CCC1=C(C)CN(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCC(C)CC3)cc2)C1=O |
| Molecular Species | |
| Max Phase |
Maximum phase of development reached for the compound (4 = approved).
Null where max phase has not yet been assigned.
|
| Molecular Weight |
490.626
Molecular weight.
|
| CX ALogP |
Calculated ALogP.
|
| CX LogD7.4 |
The calculated octanol/water distribution coefficient at pH7.4 using ACDlabs.
|
| Log P (Crippen method) |
3.074
Wildman-Crippen LogP value. Wildman and Crippen JCICS 39:868-73 (1999)
|
| CX Acidic pka |
The most acidic pKa calculated using ACDlabs.
|
| CX Basic pka |
The most basic pKa calculated using ACDlabs.
|
| HB Acceptor |
5
Number hydrogen bond acceptors.
|
| HB Donor |
3
Number hydrogen bond donors.
|
| TPSA |
124.680
Topological polar surface area.
|
| QED Weight |
Weighted quantitative estimate of drug likeness (as defined by Bickerton et al., Nature Chem 2012).
|
Drug features
Excipient information
| Name | Lactose |
| SMILES | C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O |
| CAS | 63-42-3 |
| Melting point | 232 |
| Density> | 1.589 |
| Description | Lactose (Henrifarma) |
| Synonyms | Anhydrous 60M; Anhydrous Direct Tableting (DT); Anhydrous DT High Velocity; Anhydrous Impalpable; Lactopress Anhydrous; Lactopress Anhydrous 250; lactosum anhydricum; lattosio; milk sugar; SuperTab 21AN; SuperTab 22AN; saccharum lactis |
| Related sunstances | Lactose, inhalation; lactose, monohydrate; lactose, spray-dried |
| Functional category | Directly compressible tablet excipient; dry powder inhaler carrier; lyophilization aid; tablet and capsule diluent; tablet and capsule filler |
| Conditions | Mold growth may occur under humid conditions (80% RH and above). Lactose may develop a brown coloration on storage, the reaction being accelerated by warm, damp conditions. At 80℃ and 80% RH, tablets containing anhydrous lactose have been shown to expand 1.2 times after one day. Lactose anhydrous should be stored in a well-closed container in a cool, dry place. |